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High reproductive compatibility between crops and their wild relatives can provide benefits for crop breeding but also poses risks for agricultural weed evolution. Weedy rice is a feral relative of rice that infests paddies and causes severe crop losses worldwide. In regions of tropical Asia where the wild progenitor of rice occurs, weedy rice could be influenced by hybridization with the wild species. Genomic analysis of this phenomenon has been very limited. Here we use whole genome sequence analyses of 217 wild, weedy and cultivated rice samples to show that wild rice hybridization has contributed substantially to the evolution of Southeast Asian weedy rice, with some strains acquiring weed-adaptive traits through introgression from the wild progenitor. Our study highlights how adaptive introgression from wild species can contribute to agricultural weed evolution, and it provides a case study of parallel evolution of weediness in independently-evolved strains of a weedy crop relative.

 

The scaffold protein PSD-95 links postsynaptic receptors to sites of presynaptic neurotransmitter release. Flexible linkers between folded domains in PSD-95 enable a dynamic supertertiary structure. Interdomain interactions within the PSG supramodule, formed by P DZ3, S H3, and G uanylate Kinase domains, regulate PSD-95 activity. Here we combined discrete molecular dynamics and single molecule Förster resonance energy transfer (FRET) to characterize the PSG supramodule, with time resolution spanning picoseconds to seconds. We used a FRET network to measure distances in full-length PSD-95 and model the conformational ensemble. We found that PDZ3 samples two conformational basins, which we confirmed with disulfide mapping. To understand effects on activity, we measured binding of the synaptic adhesion protein neuroligin. We found that PSD-95 bound neuroligin well at physiological pH while truncated PDZ3 bound poorly. Our hybrid structural models reveal how the supertertiary context of PDZ3 enables recognition of this critical synaptic ligand. 

Abstract This study investigates the intensity change of binary tropical cyclones (TCs) in idealized cloud-resolving simulations. Four simulations of binary interaction between two initially identical mature TCs of about 70 ms −1 with initial separation distance varying from 480 to 840 km are conducted in a quiescent f -plane environment. Results show that two identical TCs finally merge if their initial separation distance is within 600 km. The binary TCs presents two weakening stages (stages 1 and 3) with a quasi-steady evolution (stage 2) in between. Such intensity change of one TC is correlated with the upper-layer vertical wind shear (VWS) associated with the upper-level anticyclone (ULA) of the other TC. The potential temperature budget shows that eddy radial advection of potential temperature induced by large upper-layer VWS contributes to the weakening of the upper-level warm core and thereby the weakening of binary TCs in stage 1. In stage 2, the upper-layer VWS first weakens and then re-strengthens with relatively weak magnitude, leading to a quasi-steady intensity evolution. In stage 3, due to the increasing upper-layer VWS, the non-merging binary TCs weaken again until their separation distance exceeds the local Rossby radius of deformation of the ULA (about 1600 km), which can serve as a dynamical critical distance within which direct interaction can occur between two TCs. In the merging cases, the binary TCs weaken prior to merging because highly asymmetric structure develops as a result of strong horizontal deformation of the inner core. However, the merged system intensifies shortly after merging.